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Read about Paroxetine, a medication that works in the brain to treat major depressive disorder.PAXIL® (paroxetine hydrochloride) Tablets and Oral Suspension. Suicidality and Antidepressant Drugs. Antidepressants increased the risk compared.Jun 5, 2018 Paxil, one of the most commonly prescribed drugs for anxiety and it works on the serotonin system in your brain,” says Alison Hermann, M.D., .Paxil increases serotonin levels and is used for treating depression and other mental illnesses. This drug should not be combined with MAOIs.Paroxetine, also known by the trade names Aropax, Paxil, Pexeva, Seroxat, Sereupin and Brisdelle, was first marketed in the U.S. in 1992. Effective for major .